GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs5758659 | 1 | rs134882 | chr22:42670965 | CYP2D6 | chr22:42522502-42526883:- | -0.71 | -7.7 | 1.28E-11 | Cognitive function |
| THYM | cis | rs5758659 | 1 | rs134900 | chr22:42683343 | CYP2D6 | chr22:42522502-42526883:- | -0.68 | -7.23 | 1.2E-10 | Cognitive function |
| THYM | cis | rs5758659 | 1 | rs134902 | chr22:42683997 | CYP2D6 | chr22:42522502-42526883:- | -0.67 | -7.14 | 1.89E-10 | Cognitive function |
| THYM | cis | rs10935120 | 1 | rs1357762 | chr3:134264859 | ANAPC13 | chr3:134196547-134204865:- | 0.56 | 7.61 | 1.94E-11 | Height |
| THYM | cis | rs10935120 | 1 | rs1357762 | chr3:134264859 | CEP63 | chr3:134204575-134293852:+ | 0.41 | 6 | 3.54E-8 | Height |
| THYM | cis | rs7849270 | 1 | rs1360172 | chr9:131907980 | CRAT | chr9:131857075-131873070:- | 0.38 | 4.61 | 1.24E-5 | Blood metabolite ratios |
| THYM | cis | rs2028299 | 1 | rs1371135 | chr15:90391270 | AP3S2 | chr15:90373832-90456222:- | -0.39 | -4.48 | 2.08E-5 | Type 2 diabetes |
| THYM | cis | rs6540731 | 1 | rs1389369 | chr1:212400536 | NEK2 | chr1:211836115-211848967:- | -0.17 | -4.53 | 1.74E-5 | Intelligence (childhood) |
| THYM | cis | rs6540731 | 1 | rs1389370 | chr1:212400617 | NEK2 | chr1:211836115-211848967:- | -0.17 | -4.53 | 1.74E-5 | Intelligence (childhood) |
| THYM | cis | rs2243480 | 1 | rs1392104 | chr7:65759107 | CCT6P1 | chr7:65216092-65228661:+ | -0.64 | -5.29 | 7.77E-7 | Diabetic kidney disease |
| THYM | cis | rs17174870 | 1 | rs1400321 | chr2:112670046 | MERTK | chr2:112656191-112786945:+ | 0.25 | 4.15 | 7.36E-5 | Multiple sclerosis |
| THYM | cis | rs1401999 | 1 | rs1402003 | chr3:183642879 | ABCC5 | chr3:183637726-183735727:- | 0.48 | 4.21 | 5.7E-5 | Anterior chamber depth |
| THYM | cis | rs9309473 | 1 | rs1403284 | chr2:73726662 | ALMS1P | chr2:73872046-73912692:+ | -0.62 | -4.41 | 2.71E-5 | Metabolite levels |
| THYM | cis | rs2243480 | 1 | rs1404147 | chr7:65264524 | CCT6P1 | chr7:65216092-65228661:+ | 0.7 | 5.35 | 6.04E-7 | Diabetic kidney disease |
| THYM | cis | rs2463822 | 1 | rs1406384 | chr11:62083530 | ASRGL1 | chr11:62104774-62160885:+ | -0.56 | -5.68 | 1.44E-7 | Chronic obstructive pulmonary disease-related biomarkers |